Regulated Spectroscopy ServicesIreland & UK

Chemometric Model Development & Multivariate Spectral Analytics

Application-led quantitative calibration, qualitative classification models, and continuous lifecycle maintenance for regulated laboratories and manufacturing teams across Ireland and the UK.

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GAMP 5 & Data Integrity

Full audit trail & model qualification

PLS, PCA & SIMCA

Advanced multivariate algorithms

Lifecycle Verification

Drift monitoring & model updates

Spectral Matrix21 CFR Part 11
Supported Modalities
Multi-vendor instrument chemometrics & PAT integration.
NIR Spectroscopy780 – 2500 nm

Moisture, blend uniformity, drying endpoint & raw material ID

Raman Spectroscopy100 – 3400 cm⁻¹

Polymorph screening, reaction monitoring & non-destructive ID

UV-Vis Spectroscopy190 – 1100 nm

Concentration dynamics, dissolution & protein quantification

FTIR Spectroscopy4000 – 400 cm⁻¹

Functional group verification, polymer profiling & QC release

Method transfer supportView PAT Suite
Chemometric & Analytical Engineering

Specialized Calibration and Multivariate Capabilities

Application-led model development, method validation, and cross-platform transfer designed specifically for GMP pharmaceutical, chemical, and industrial manufacturing.

Core Modeling
Quantitative & Qualitative Calibration Model Building
PLS, PCR, PCA & SIMCA Algorithms
Robust chemometric models tailored for raw material identification, blend uniformity, and active ingredient assay in regulated environments.

Includes: Model validation documentation, outlier diagnostics, and precision verification.

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Lifecycle Support
Routine Model Maintenance & Optimization
Continuous Lifecycle Monitoring
Scheduled calibration drift analysis, slope and intercept adjustments, and expansion for new sample matrix variations and raw material suppliers.

Includes: Periodic health reviews, re-calibration reports, and change control support.

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Standardization
Optical Method Transfer & Cross-Instrument Standardization
Seamless Instrument Equivalency
Standardization protocols to transfer existing spectral libraries and quantitative methods between benchtop spectrometers and inline process probes.

Includes: Transfer protocol design, statistical equivalency tests, and risk assessments.

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Advanced MVA
Advanced Multivariate Data Analysis
PAT & Real-Time Quality Control
Multi-parameter process modeling combining inline spectral streams with critical quality attributes for batch release and endpoint determination.

Includes: Trajectory monitoring setups, alarm limit definitions, and automated data pipelines.

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Need model development or feasibility verification on your samples?

Our spectroscopy specialists evaluate your spectral data and define optimal calibration strategies.

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Process Analytics

Real-time process monitoring from development to full-scale manufacturing

Streamline batch release, prevent failed runs, and gain deep process understanding with proven PAT spectroscopic solutions engineered for regulated production facilities.

Turnkey Implementation

Validated hardware & qualification packages (IQ/OQ/PQ)
Direct chemometric model development and tech transfer
Dedicated field support across Ireland and the UK
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Integrated Systems
Process Analytical Technology Solutions
Comprehensive in-line, on-line, and at-line analytical setups designed for blend uniformity, drying endpoint, and real-time release testing.
Continuous verification • Non-destructive • 21 CFR Part 11 compliant
High-Resolution FT-NIR & Raman
Bruker PAT Spectroscopic Family
Robust process spectrometers including MATRIX-F II, BEAM, and Process Guardian for harsh manufacturing environments and reactor monitoring.
Multi-point fiber coupling • Solid & liquid sampling • IP65 rated
Ultra-Compact NIR
VIAVI MicroNIR Family
Miniature, fit-for-purpose NIR spectrometers for rotary blenders, fluid beds, and portable field analysis with wireless data transfer.
PAT-W & PAT-U units • ATEX / IECEx certified • Low maintenance

Need method development or feasibility testing?

Our team provides hands-on spectroscopic application testing.

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Specialist Services

Targeted Technical Capabilities

From initial spectral suitability testing to full inline deployment and chemometric modeling, we help teams solve complex measurement challenges.

Method & Validation
Application Development & Consultation
Tailored spectroscopic and analytical method development, spectral library building, and regulatory transfer support for regulated pharmaceutical and industrial processes.

Included Support

  • Custom NIR and Raman chemometric model building
  • Method transfer and laboratory-to-process scale-up
  • Direct guidance from analytical application specialists
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Trial & Feasibility
PAT Feasibility Studies
De-risk real-time process analytical technology investments with structured sample testing, proof-of-concept trials, and clear suitability reporting before deployment.

Included Support

  • Off-line and inline spectral feasibility assessments
  • Quantitative measurement precision and limit evaluation
  • Comprehensive feasibility summary and hardware recommendation
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Need guidance on spectroscopy instrumentation?

Speak directly with an instrumentation engineer about your specific sample requirements.

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Application Engineering

Technical Consultation & Application Scoping

Partner directly with our senior analytical specialists to evaluate your method requirements, test instrument compatibility, and outline compliant implementation paths for regulated environments.

Spectral Data Review

Comprehensive feasibility assessment of NIR, Raman, or powder sample spectra with signal-to-noise evaluation.

Model Architecture Recommendation

Tailored chemometric models, hardware selection, and integration strategy for process analytics.

Compliance Scoping

Alignment with GMP, 21 CFR Part 11, and site-specific validation protocols across UK and Irish facilities.

Trusted across pharmaceutical, chemical, and regulated manufacturing sites throughout Ireland and the United Kingdom.

Contact Us – Antech Solutions

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